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KMID : 0986520090090020065
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Korean Journal of Endoscrine Surgery
2009 Volume.9 No. 2 p.65 ~ p.68
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Follicular Variant of Papillary Thyroid Carcinoma; Clinicopathologic Features
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Kim Shinn-Young
Chae Byung-Joo
Jung So-Lyung
Jung Chang-Yeon
Lim Dong-Jun
Song Byung-Joo
Kim Jeong-Soo
Kim Seung-Nam
Bae Ja-Seong
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Abstract
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Purpose: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common subtype of papillary thyroid carcinoma (PTC). However, the clinicopathologic features of patients with FVPTC with those of patients with pure PTC is ill-understood. This study evaluated differences in clinicopathologic features of FVPTC compared with pure PTC.
Methods: All patients with FVPTC or pure PTC diagnosed between January 2006 and August 2008 at our institution were retrospectively reviewed. The two groups were compared in terms of clinocopathological features.
Results: Of 417 patients, 370 had PTC, and 47 patients had FVPTC. The meanage was 47.1 years. There was no differencein age and sex ratio between the two groups, and both groups were similar in terms of tumor size, presence of multifocality, thyroid capsular invasion, and extrathyroidal extension. However, FVPTC patients had significantly lower lymph node metastases (P=0.015) and significantly higher tumor encapsulation (P=0.031). Galectin-3 expression was decreased in FVPTC (P=0.012).
Conclusion: The clinicopathologic features of FVPTC are more favorable. The possibility of FVPTC could be considered when thyroid nodules with negative galectin-3 expression have suspicious or malignant fine needle aspiration biopsy.
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KEYWORD
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Papillary thyroid cancer, Pure papillary thyroid cancer, Follicular variant
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